Hashimoto encephalopathy (HE) is an uncommon syndrome associated with Hashimoto thyroiditis Cantón A, de Fàbregas O, Tintoré M, et al. Request PDF on ResearchGate | On Jun 1, , Paloma Bacarizo and others published Encefalopatía de Hashimoto en un paciente de 20 años. CLINICAL/SCIENTIFIC NOTE. Hashimoto’s encephalopathy. Encefalite de Hashimoto. Renata Telles Rudge de AquinoI; Eduardo Genaro MutarelliII.

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Anti-thyroperoxidase antibodies anti-TPO was 1.

It is recommended to reduce the dose of steroids over several months. The rest of the physical examination was normal. Received 6 Novemberreceived in final form 30 March Received 18 Junereceived in final form 1 September The first case of HE was described by Brain et al. Hypothyroidism, hormonal factors and cerebral hypoperfusion could contribute for pathogenesis 2.

She had three pregnancies with normal gestation, last 9 years ago. Degenerative SA Friedreich’s ataxia Ataxia-telangiectasia. In an epidemiological study encefalopata by Seipelt et al. However, the final diagnosis is obtained through a neuropathological exam 9. It is associated with Hashimoto’s thyroiditis. Consistent with this hypothesis, autoantibodies to alpha-enolase have been encefalopatai to be associated with Hashimoto’s encephalopathy.

InBrain et al. Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto’s encephalopathy. Although it has been linked to cases of Hashimoto’s thyroiditis or thyroid dysfunction, the most common immunological feature of HE is the presence of high titers of antithyroglobulin or anti-TPO antimicrosomal antibodies.

Hashimoto’s encephalopathy

Neuroendocrinology Brain disorders Autoimmune diseases Steroid-responsive inflammatory conditions. Normotensive, pulse bpm, she had universal alopecia, cyanosis and pale alternating in the extremities, growing nails encrfalopatia the right hand and scars on her back and face. We believe that this pathology is misdiagnosed, therefore, tests detecting the presence of anti-thyroid antibodies are recommended in a clinical presentation of encephalopathy of subacute onset or rapidly progressive dementia associated with myoclonus and triphasic complexes in the EEG, when the ethiology is not identified.


At present, it is unclear whether antithyroid antibodies represent an immune epiphenomenon in a subset of patients with encephalopathic processes or they are really associated with pathogenic mechanisms of the disorder.

The magnetic resonance imaging MRI of the brain showed small changes that were not significant, such as the presence of hypersignal focus in the corona radiata encefalo;atia bilaterally semioval center Fig 1. Episodes of sinus tachycardia of bpm followed, with normal cardiac investigations. Oligoclonal bands were absent.

Little is known about the pathogenesis.

J Clin Endocrinol Metab ; Brain herniation Reye’s Hepatic encephalopathy Toxic encephalopathy Hashimoto’s encephalopathy. Long-term treatment of Hashimoto’s encephalopathy. All the contents of this journal, except encefaloptaia otherwise noted, is licensed under a Creative Commons Attribution License. In this period there was a regression of all signs and symptoms.

How to cite this article.

Its two sub-types can co-exist: Thyroid antibodies — both anti-thyroid peroxidase antibodies anti-TPO, anti-thyroid microsomal antibodies, anti-M and anti thyroglobulin antibodies anti-Tg — in the disease are elevated but their levels do not correlate with the severity.

MRI and cerebral angiography are normal in the majority of cases 2. It was suggested that the hypocampus, hypothalamus and hair follicles form a molecular target for auto-immunity, the so-called ‘triple H’ syndrome 6. SPECT can be normal encdfalopatia usually shows focal hypoperfusion 8. It is probably hasihmoto diagnosed as it is not well known 5. Brain Encephalitis Viral encephalitis Herpesviral encephalitis Limbic encephalitis Encephalitis lethargica Cavernous sinus thrombosis Brain abscess Amoebic.


The patient authorized the publication of the case upon signature of an informed consent form. The most common abnormality is diffuse encefalopwtia signal in the white substance 2.

Hashimoto’s encephalopathy – Wikipedia

Department of Medical Genetics. She had a history of hypothyroidism and did not use any medication. Hashimoto’s encephalopathy HE is a controversial neurological disorder that comprises a heterogenous group of neurological symptoms that manifest in patients with high titers of antithyroid antibodies.

Failure of some patients to respond to this first line treatment has produced a variety of alternative treatments including azathioprinecyclophosphamidechloroquinemethotrexateperiodic intravenous immunoglobulin and plasma exchange.

Duration of treatment is usually between 2 and 25 years. Steroid-responsive encephalopathy associated with autoimmune thyroiditis. She was stable, suggesting a hypothalamic dysfunction. Between and 43 cases were published.

Some aspects warrant particular attention: There are EEG changes in most cases, mainly general slowing 2,8.

Japan, and Depannient of Anatomy and Biology. The clinical improvement can occur on the first day, like in this case, but generally occurs within a week and up to 6 weeks 8. Encephalomyelitis Acute disseminated Myalgic Meningoencephalitis. Hashimoto’s encephalitis as a differential diagnosis of Creutzfeldt-Jakob disease.

A relapsing encephalopathy occurring in association with Hashimoto’s thyroiditiswith high titers of anti-thyroid antibodies. How to cite this article.