Carcinoma nasofaríngeo. Rev Med Cos Cen ; 72 (). Language: Español References: Page: PDF: Kb. [Full text – PDF]. ABSTRACT. Since its discovery 50 years ago, Epstein-Barr virus (EBV) has been linked to the development of cancers originating from both lymphoid and epithelial cells. Request PDF on ResearchGate | Carcinoma nasofaríngeo familiar en zona no endémica. Presentación de 3 familias | Nasopharyngeal carcinoma is the.

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Questo potrebbe essere confermato dalla correlazione riscontrata tra livello di sostanze immunosoppressive e progressione neoplastica nei soggetti malati [52]. Undifferentiated, nonkeratinizing, and nsofaringeo cell carcinoma of the nasopharynx.

URL consultato il 15 febbraio URL consultato il 12 febbraio EBER-1 expression in thymic carcinoma. Case of the Week Analysis of the EBV genome in a number of BL cell lines revealed gross deletions, some of which account for biological differences.

Head and neck cancer of respiratory tract Epstein—Barr cardinoma diseases Infectious causes of cancer Pharynx. Services on Demand Journal. Cerebellopontine angle involvement by nasopharyngeal carcinoma.

EBV infection as detected by in situ hybridization to the abundantly expressed non-polyadenylated EBER RNAs has been demonstrated in high-grade severe dysplastic and carcinoma in situpreinvasive lesions in the nasopharynx, but not in low-grade disease or histologically normal nasopharyngeal epithelium [35][79].

Tzellos S, Farrell PJ. Editorial Board Member Review: Epstein-Barr virus EBV was the first human tumor virus to be discovered and has yielded significant insight into both the pathogenesis of cancer and the natural history of persistent herpesvirus infection.


However, these studies focused on specific regions of the EBV genome rather than on comparing the cxrcinoma viral DNA sequence.

Epstein-Barr virus and nasopharyngeal carcinoma

D ICD – NPC is uncommon in the Nawofaringeo States and most other nations, representing less than 1 case perin most populations. A case report and review of the literaturein Oncol Lettvol. Visite Leggi Modifica Modifica wikitesto Cronologia.

NPC occurs in children and adults. The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Epstein-Barr virus EBV and its associated human cancers—genetics, epigenetics, pathobiology and novel therapeutics. I paesi di minore diffusione sono quelli africani e del sud America [7].

In addition to this broad distinction between EBV types 1 and 2, there is also minor heterogeneity within each virus type. Computed tomography of nasopharyngeal carcinoma.

There are several well-described forms of EBV latency, each of which nasofarngeo virus uses at different stages of the viral life cycle and which are also reflected in the patterns of latency observed in various EBV-associated malignancies [2][5]. Identification of functional differences between prototype Epstein-Barr virus-encoded LMP1 and a nasopharyngeal carcinoma-derived LMP1 in human epithelial cells.

Studi ccarcinoma sembrano comunque restringere l’importanza dell’azione diretta nel caso del tumore orale, sostenendo invece una quasi esclusiva azione di potenziamento in associazione con il fumo [32] [33]. Only comments seeking to improve the quality nasofzringeo accuracy of information on the Orphanet website are accepted. URL consultato il 27 gennaio The recommended treatment schedule consists of three courses of neoadjuvant chemotherapy, irradiation, and adjuvant interferon IFN -beta therapy.


Carcinoma della bocca

Furthermore, a detailed appreciation of the function of these EBV latent genes could provide opportunities to develop novel diagnostic and therapeutic approaches. Retrieved from ” https: Recent immigrant from Hong Kong presented with nasal discharge and a nasopharyngeal mass was biopsied.

This model proposes that loss of heterozygosity LOH occurs early in NPC pathogenesis, possibly as a result of exposure to environmental cofactors such as dietary components e. Orphanet Journal of Rare Diseases. Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells. Anteriormente, comunica-se com a cavidade nasal via coana posterior.

URL consultato il 12 febbraio archiviato dall’ url originale il 16 aprile Radiation therapy is the mainstay of treatment for all histologic types of nasopharyngeal carcinoma NCCN: Journal List Chin J Cancer v.

All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Altre neoplasie benigne dei tessuti molli come il fibroma o il raro tumore a cellule granulose, di origine neurogena, possono richiedere l’esame istologico per eliminare il dubbio diagnostico.

GC remains the nnasofaringeo leading cause of death from cancer. The presence of monoclonal EBV episomes in NPC indicates that viral infection precedes the clonal expansion of malignant cells [13].